|
KMID : 0378019860290110109
|
|
New Medical Journal
1986 Volume.29 No. 11 p.109 ~ p.113
|
|
|
Clinical Efficacy of Diethylamine Chromone Carboxylate (Fludarene^(®)) in Patients with Diabetic Neuropathy
|
|
|
|
|
Abstract
|
|
|
|
20 patients with diabetic neuropathy were treated with an aldose reductase inhibitor (Fludarene®). Daily dose was 600mg for 4 weeks. Response was assessed according to a 0-4 scale for pain and single maximal breathing test for cardiac autonomic nerve function. 11 patients had moderate to marked relief of symptoms, 3 had mild responses, and 6 had no change. During the course of treatment autonomic nerve function improved significantly in 5 of 8 patients tested. Little toxicity was observed. These observation suggest that an aldose reductase inhibitor (Fludarene®) may be effective and safe in the treatment of symptomatic peripheral and autonomic neuropathies complicating diabetes.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|